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* Process Research & Development.
Process philosophy:
Innovation; fewest steps; fewest solvents; maximize productivity per step; employ through processing; minimize protecting groups; catalytic methods; avoid dangerous reagents; atom economy; minimize waste; minimize energy usage; avoid classical resolutions
Process Service:
Synthetic route design, evaluation and scouting;
Process development and optimization to reduce cost and maximize throughput;
Analytical method development for in-process control and final product analysis;
Evaluation of processes for environmental health and safety issues;
Identification of impurity profiles for raw materials, intermediates, and final products.
Case:
| Steps | Reagents | Overall Yield | Product | |
|---|---|---|---|---|
| Initial Process | 6 | Expensive ,Dangerous(LAH,BBr3) | 35.2% | Off-white |
| Optimized Process | 5 | Cheap and safe(KBH4,AlCl3) | 52.5% | White(good work-up and crystallization method) |
* FTE contract in Process Research & Development.
Our FTE-based projects focus on the process chemistry to aid pharmaceutical process research and development efforts.
* Crystallization method to explore and services
Crystallization is the essence of enjoypharm, we offer the service of crystallization for you
* Custom Synthesis and Manufacturing.
Custom synthesis in laboratory scales (milligrams to kilograms)
Custom Manufacturing contract with our joint manufacture partner (kilograms to tons)
enjoypharm particularly specialized in such reactions: Friedel-Crafts, Oxidation, Reduction, Nitrosation, Bromination, Coupling
* Drug Discovery Support Service
Small-scale synthesis of lead drug candidates, lead analogs and scaffolds; Reference standard, impurity and metabolite preparations
Analytical method development and validation;
Stability studies;
Analytical characterization;
Reference standard qualification;
Quality control analysis.